Overexpressing Adrenomedullin in Their Vasculature Hypotension and Resistance to Lipopolysaccharide-Induced Shock in Transgenic Mice
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چکیده
Izumida, Naoto Minamino, Ki-Hwan Ju, Hiroyuki Morita, Yoshio Oh-hashi, Mamoru Kumada, Takayuki Shindo, Hiroki Kurihara, Koji Maemura, Yukiko Kurihara, Tomoyuki Kuwaki, Taro Overexpressing Adrenomedullin in Their Vasculature Hypotension and Resistance to Lipopolysaccharide-Induced Shock in Transgenic Mice Print ISSN: 0009-7322. Online ISSN: 1524-4539 Copyright © 2000 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Circulation doi: 10.1161/01.CIR.101.19.2309 2000;101:2309-2316 Circulation. http://circ.ahajournals.org/content/101/19/2309 World Wide Web at: The online version of this article, along with updated information and services, is located on the
منابع مشابه
Hypotension and resistance to lipopolysaccharide-induced shock in transgenic mice overexpressing adrenomedullin in their vasculature.
BACKGROUND Adrenomedullin (AM) is a vasodilating peptide involved in the regulation of circulatory homeostasis and in the pathophysiology of certain cardiovascular diseases. To determine the extent to which chronic AM overproduction affects circulatory physiology under normal and pathological conditions, we used a preproendothelin-1 promoter to establish transgenic mouse lines overexpressing AM...
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